Description

4-Chloro-2,6-Difluorophenol is a halogenated phenol derivative that serves as a versatile and critical building block in advanced organic synthesis. Its unique structure, featuring chlorine and fluorine substituents, makes it a valuable intermediate for creating complex molecules with tailored properties. This compound is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a difluorophenol core structure.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and pesticides where the halogenated phenol moiety enhances biological activity.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorine-containing compounds used in electronic display technologies.
• Polymer Modification: Intermediate for introducing halogenated phenolic groups into polymers to alter thermal stability, flame retardancy, or solubility.
• Organic Synthesis Reagent: Employed in cross-coupling reactions, etherification, and as a protecting group precursor in complex multi-step syntheses.
• Research & Development: A valuable tool for medicinal chemistry and material science research exploring new chemical entities.

Basic Information

Product Name	4-Chloro-2,6-Difluorophenol
CAS No.	164790-68-5
Molecular Formula	C6H3ClF2O
Molecular Weight	164.54 g/mol
Synonyms	2,6-Difluoro-4-chlorophenol; 4-Chloro-2,6-difluorophenol; Phenol, 4-chloro-2,6-difluoro-; 4-Chloro-2,6-difluoro-1-hydroxybenzene; 1-Chloro-3,5-difluoro-4-hydroxybenzene
EINECS	Contact for details

Quality Control

Our 4-Chloro-2,6-Difluorophenol is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full traceability are provided for each shipment. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet your project's specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	48 - 52 °C
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.