Description

(R)-3-Ethoxy-Pyrrolidine Hydrochloride is a high-purity chiral building block and intermediate of significant importance in advanced organic synthesis. Its defined stereochemistry and functionalized pyrrolidine core make it a valuable scaffold for constructing complex molecules with specific biological activity. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) targets and other therapeutic areas.
• Medicinal Chemistry: Used as a constrained scaffold to explore structure-activity relationships (SAR) and to introduce the ethoxy-pyrrolidine moiety into drug candidates to modulate potency, selectivity, and pharmacokinetic properties.
• Asymmetric Synthesis: Serves as a starting material or intermediate in catalytic asymmetric reactions to produce enantiomerically pure compounds.
• Agrochemical Research: Employed in the synthesis of advanced crop protection agents and pesticides where specific chirality can influence biological efficacy.
• Ligand and Catalyst Development: Utilized for the preparation of chiral ligands and organocatalysts used in stereoselective transformations.
• Chemical Biology Probes: Acts as a building block for creating molecular probes to study biological pathways and enzyme functions.

Basic Information

Product Name	(R)-3-Ethoxy-Pyrrolidine Hydrochloride
CAS No.	164790-65-2
Molecular Formula	C6H14ClNO
Molecular Weight	151.64 g/mol
Synonyms	(R)-3-Ethoxypyrrolidine hydrochloride; (3R)-3-Ethoxypyrrolidine hydrochloride; (R)-3-Ethoxy-pyrrolidine HCl; Pyrrolidine, 3-ethoxy-, hydrochloride, (3R)-; 3-Ethoxy-(R)-pyrrolidine hydrochloride; (R)-3-Ethoxy-1-azacyclopentane hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-3-Ethoxy-Pyrrolidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.