Description

4-(Fmoc-Aminomethyl)Benzoic Acid is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). This compound serves as a critical building block, enabling the controlled and sequential assembly of complex peptides and peptidomimetics. It is primarily utilized by research institutions, pharmaceutical developers, and CROs engaged in drug discovery, proteomics, and the development of therapeutic peptides and bioconjugates.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected linker for the automated synthesis of peptides on resin.
• Drug Discovery & Medicinal Chemistry: Used to incorporate a benzoic acid moiety with a protected amine handle into target molecules for structure-activity relationship (SAR) studies.
• Bioconjugation & Labeling: Facilitates the site-specific attachment of peptides, drugs, or fluorescent probes to antibodies, proteins, or nanoparticles via its carboxylic acid group.
• Combinatorial Library Synthesis: Employed in the generation of diverse chemical libraries for high-throughput screening against biological targets.
• Proteomics Research: Used in the synthesis of peptide antigens, enzyme substrates, or inhibitors for biochemical assays.
• Material Science: Can serve as a functional monomer or cross-linker for creating specialized polymers with bioactive properties.

Basic Information

Product Name	4-(Fmoc-Aminomethyl)Benzoic Acid
CAS No.	164470-64-8
Molecular Formula	C24H21NO4
Molecular Weight	387.43 g/mol
Synonyms	Fmoc-AMB-OH; 4-[[(9H-Fluoren-9-ylmethoxy)carbonyl]aminomethyl]benzoic Acid; N-[(9-Fluorenylmethoxy)carbonyl]-4-(aminomethyl)benzoic Acid; 4-(Fmoc-aminomethyl)benzoic Acid; 4-(N-Fmoc-aminomethyl)benzoic Acid; Fmoc-protected 4-aminomethylbenzoic Acid; AMB(Fmoc)-OH; (4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)methyl)benzoic Acid
EINECS	Contact for details

Quality Control

Our 4-(Fmoc-Aminomethyl)Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and MS for identity verification, to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.