Description

(2S)-2-Hydroxy-2-Methyl-3-Phenylpropanoic Acid is a high-purity chiral building block and intermediate of significant interest in advanced organic synthesis. Its value lies in its defined stereochemistry and functional groups, which are critical for constructing complex molecules with specific biological activity. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical and fine chemical industries for applications such as drug discovery and the development of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and production of enantiomerically pure drugs, particularly in central nervous system (CNS) and metabolic disorder therapeutics.
• Asymmetric Synthesis: Used as a starting material or resolving agent in catalytic asymmetric reactions to introduce stereogenic centers.
• Fine Chemical Production: Serves as a precursor for specialty chemicals, including advanced ligands, catalysts, and fragrances.
• Academic & Industrial Research: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and novel compound library synthesis.
• Agrochemical Development: Potential intermediate in the synthesis of chiral pesticides or herbicides where specific isomer activity is required.

Basic Information

Product Name	(2S)-2-Hydroxy-2-Methyl-3-Phenylpropanoic Acid
CAS No.	164333-77-1
Molecular Formula	C10H12O3
Molecular Weight	180.20 g/mol
Synonyms	(S)-2-Hydroxy-2-methyl-3-phenylpropanoic acid; (S)-2-Hydroxy-2-methyl-3-phenylpropionic acid; (S)-α-Hydroxy-α-methylhydrocinnamic acid; (S)-2-Methyl-2-hydroxy-3-phenylpropanoic acid; L-2-Hydroxy-2-methyl-3-phenylpropanoic acid; (2S)-2-Hydroxy-2-methyl-3-phenylpropionic acid; (S)-HMPPA
EINECS	Contact for details

Quality Control

Our (2S)-2-Hydroxy-2-Methyl-3-Phenylpropanoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.