Description

(2R, 4S)-4-Hydroxytetrahydrofuran-2-Methanol CAS NO 164267-54-3 is a high-purity chiral building block and pharmaceutical intermediate. This compound is valued for its stereochemically defined structure, which is critical for synthesizing enantiomerically pure active pharmaceutical ingredients (APIs) and fine chemicals. It is primarily required by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel therapeutic agents and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug molecules, particularly in antiviral, anticancer, and cardiovascular therapies.
• Asymmetric Synthesis: Used as a precursor or auxiliary in catalytic asymmetric reactions to introduce stereogenic centers.
• Agrochemical Research: Serves as a building block for developing enantiomerically pure pesticides and herbicides.
• Ligand and Catalyst Development: Utilized in the preparation of chiral ligands for metal-catalyzed transformations.
• Polymer Chemistry: Acts as a monomer or cross-linking agent for synthesizing functionalized polymers with specific optical properties.
• Academic & R&D: Employed in organic chemistry research for methodological studies and the discovery of new synthetic pathways.

Basic Information

Item	Detail
Product Name	(2R, 4S)-4-Hydroxytetrahydrofuran-2-Methanol
CAS No.	164267-54-3
Molecular Formula	C6H12O3
Molecular Weight	132.16 g/mol
Synonyms	(2R,4S)-Tetrahydro-4-hydroxy-2-furanmethanol; (2R,4S)-4-Hydroxy-2-(hydroxymethyl)tetrahydrofuran; (2R,4S)-Tetrahydro-4-hydroxy-2-furylmethanol; (2R,4S)-4-Hydroxytetrahydro-2-furanmethanol; (2R-cis)-Tetrahydro-4-hydroxy-2-furanmethanol; (2R,4S)-THF diol derivative; Chiral THF methanol derivative
EINECS	Contact for details

Quality Control

Our (2R, 4S)-4-Hydroxytetrahydrofuran-2-Methanol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.