Description

(2R, 4R)-4-Hydroxytetrahydrofuran-2-Methanol CAS NO 164267-53-2 is a high-purity chiral building block and versatile synthon of significant importance in advanced organic synthesis. Its value lies in its stereochemically defined structure, which is critical for imparting specific biological activity and physical properties in final target molecules. This compound is essential for research and production in the pharmaceutical industry, particularly for the development of active pharmaceutical ingredients (APIs), nucleoside analogs, and complex natural products.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of nucleoside-based antiviral and anticancer drugs.
• Asymmetric Synthesis: Used as a chiral auxiliary or starting material for constructing complex, stereodefined molecular architectures.
• API Development: Serves as a critical building block in the research and scale-up of new active pharmaceutical ingredients (APIs).
• Natural Product Synthesis: Employed in the total synthesis of complex natural products requiring specific stereochemistry.
• Ligand and Catalyst Preparation: Useful for synthesizing chiral ligands and organocatalysts used in enantioselective reactions.
• Fine Chemical Production: Applied in the manufacture of high-value specialty chemicals and advanced materials.

Basic Information

Product Name	(2R, 4R)-4-Hydroxytetrahydrofuran-2-Methanol
CAS No.	164267-53-2
Molecular Formula	C6H12O3
Molecular Weight	132.16 g/mol
Synonyms	(2R,4R)-Tetrahydro-4-hydroxy-2-furanmethanol; (2R,4R)-4-Hydroxy-2-(hydroxymethyl)tetrahydrofuran; (2R,4R)-Tetrahydro-4-hydroxy-2-furancarbinol; (2R,4R)-4-Hydroxytetrahydro-2-furanmethanol; (2R,4R)-THF-4-ol-2-methanol; (2R,4R)-4-Hydroxy-2-tetrahydrofuranylmethanol; cis-4-Hydroxytetrahydrofurfuryl alcohol (stereospecific); A chiral dihydroxy tetrahydrofuran derivative
EINECS	Contact for details

Quality Control

Our (2R, 4R)-4-Hydroxytetrahydrofuran-2-Methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent specifications for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture uptake and oxidation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.