Description

6-Bromo-4,4-Dimethylchroman-2-One is a high-purity, versatile brominated heterocyclic building block of significant interest in advanced organic synthesis. Its unique molecular scaffold, featuring a chromanone core with a bromine substituent, makes it a critical intermediate for constructing complex molecules with potential biological activity. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs) and agrochemicals, where it serves as a key precursor for coupling reactions and further functionalization.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators due to its bioactive chromanone structure.
• Material Science: Serves as a monomer or precursor for synthesizing specialized polymers and organic electronic materials.
• Academic & R&D: Employed in medicinal chemistry research for structure-activity relationship (SAR) studies and library synthesis.
• Chemical Synthesis: Acts as a versatile electrophile in cross-coupling reactions (e.g., Suzuki, Stille) for introducing the chromanone moiety into more complex architectures.
• Flavor & Fragrance Industry: Potential intermediate for synthesizing novel aroma chemicals derived from chroman structures.

Basic Information

Product Name	6-Bromo-4,4-Dimethylchroman-2-One
CAS No.	164012-31-1
Molecular Formula	C11H11BrO2
Molecular Weight	255.11 g/mol
Synonyms	6-Bromo-4,4-dimethyl-2-chromanone; 6-Bromo-4,4-dimethylchroman-2-one; 2H-1-Benzopyran-2-one, 6-bromo-3,4-dihydro-4,4-dimethyl-; 4,4-Dimethyl-6-bromochroman-2-one; 6-Bromo-4,4-dimethyl-3,4-dihydro-2H-1-benzopyran-2-one
EINECS	Contact for details

Quality Control

Every batch of 6-Bromo-4,4-Dimethylchroman-2-One is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard grade meets high-purity research specifications, with typical purity levels exceeding 97% (HPLC). A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key parameters such as assay, impurity profile, and physical characteristics. We support custom synthesis to meet specific purity or analytical requirements for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.