Description

n-Octyl-α-D-thio-mannopyranoside is a specialized synthetic thioglycoside, a critical non-ionic detergent and biochemical tool for membrane protein research. This compound is valued for its ability to solubilize and stabilize integral membrane proteins without denaturing them, facilitating their isolation and study. It is an essential reagent for structural biology, biochemistry, and pharmaceutical development laboratories working on challenging membrane-bound targets.

Application

• Membrane Protein Solubilization: Primary application for extracting and solubilizing integral membrane proteins from lipid bilayers while maintaining native structure and function.
• Structural Biology Studies: Used in the purification and crystallization of membrane proteins for X-ray crystallography and cryo-electron microscopy (cryo-EM).
• Biochemical Assay Development: Serves as a stabilizing agent in functional assays and activity measurements of G-protein coupled receptors (GPCRs), transporters, and ion channels.
• Detergent Replacement & Reconstitution: Employed in the replacement of harsher detergents and for the reconstitution of purified proteins into liposomes or nanodiscs.
• Glycobiology Research: Acts as a substrate analog or inhibitor in studies of glycosidase enzymes and carbohydrate-processing pathways due to its thioglycosidic bond.
• Pharmaceutical Screening: Utilized in drug discovery platforms targeting membrane proteins to create physiologically relevant assay conditions.

Basic Information

Product Name	n-Octyl-α-D-thio-mannopyranoside
CAS No.	163955-47-3
Molecular Formula	C₁₄H₂₈O₅S
Molecular Weight	308.43 g/mol
Synonyms	Octyl α-D-thiomannopyranoside; α-D-Octylthiomannopyranoside; n-Octyl 1-thio-α-D-mannopyranoside; OTM; Octylthiomannoside; 1-S-Octyl-1-thio-α-D-mannopyranose; α-Octylthiomannoside; n-Octyl α-D-thiomannoside
EINECS	Contact for details

Quality Control

Our n-Octyl-α-D-thio-mannopyranoside is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and specific tests for critical impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.