Description

3,3-Difluoropyrrolidine Hydrochloride is a high-purity, fluorinated heterocyclic building block essential for modern synthetic chemistry. This compound matters as a key intermediate in the development of novel active pharmaceutical ingredients (APIs), enabling the introduction of fluorine atoms to modulate the pharmacokinetic and metabolic properties of drug candidates. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries, as well as by fine chemical manufacturers specializing in custom synthesis.

Application

• Pharmaceutical Intermediate: A critical synthon for the synthesis of fluorinated drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides where the difluoropyrrolidine moiety can enhance biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics & Bioisosteres: The fluorinated pyrrolidine ring is a valuable proline bioisostere in the design of peptide-based therapeutics and enzyme inhibitors.
• Material Science: Employed in the synthesis of specialty polymers and advanced materials with unique electronic or surface properties.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects requiring high-purity, fluorinated heterocycles.

Basic Information

Product Name	3,3-Difluoropyrrolidine Hydrochloride
CAS No.	163457-23-6
Molecular Formula	C4H8F2N·HCl
Molecular Weight	155.57 g/mol (Free base: 119.11 g/mol)
Synonyms	3,3-Difluoropyrrolidine HCl; 3,3-Difluoropyrrolidine Hydrochloride Salt; 3,3-Difluoropyrrolidinium Chloride; Pyrrolidine, 3,3-difluoro-, hydrochloride; 3,3-Difluoro-1-azacyclopentane Hydrochloride; 3,3-Difluoropyrrolidine Hydrochloride (163457-23-6); 3,3-Difluoropyrrolidine HCl Salt
EINECS	Contact for details

Quality Control

Our 3,3-Difluoropyrrolidine Hydrochloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and Karl Fischer titration, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support cGMP and ISO standards for pharmaceutical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.