Description

2-(Chloromethyl)-6-Fluoroquinazolin-4(3H)-One is a high-value, multi-functional quinazolinone derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both a reactive chloromethyl group and a fluorine substituent, makes it an indispensable intermediate for constructing complex pharmacologically active molecules. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new herbicides and fungicides, leveraging the bioactivity of the quinazolinone core.
• Chemical Synthesis Building Block: The reactive chloromethyl group allows for further functionalization, making it valuable for creating custom libraries of compounds for screening.
• Material Science Research: Investigated as a monomer or precursor for specialty polymers and advanced organic materials.

Basic Information

Product Name	2-(Chloromethyl)-6-Fluoroquinazolin-4(3H)-One
CAS No.	163311-08-8
Molecular Formula	C9H6ClFN2O
Molecular Weight	212.61 g/mol
Synonyms	6-Fluoro-2-(chloromethyl)-4(3H)-quinazolinone; 2-(Chloromethyl)-6-fluoro-3,4-dihydroquinazolin-4-one; 6-Fluoro-2-(chloromethyl)quinazolin-4(3H)-one; 4(3H)-Quinazolinone, 2-(chloromethyl)-6-fluoro-; 163311-08-8; 2-Chloromethyl-6-fluoroquinazolin-4-one
EINECS	Contact for details

Quality Control

Our production of 2-(Chloromethyl)-6-Fluoroquinazolin-4(3H)-One adheres to stringent quality management protocols. Each batch is subjected to comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting regulatory filings for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.