Description

4-Difluoromethoxy-3-Ethoxy-Benzoic Acid is a high-purity, multi-functional benzoic acid derivative distinguished by its difluoromethoxy and ethoxy substituents. This compound serves as a critical advanced intermediate in the synthesis of complex active pharmaceutical ingredients (APIs) and agrochemicals, where its unique structure imparts desirable metabolic stability and bioavailability. It is essential for R&D chemists and production specialists in the pharmaceutical, agrochemical, and specialty chemical industries seeking reliable, high-quality building blocks for innovative product development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in therapeutic areas requiring fluorinated motifs for enhanced potency and pharmacokinetic properties.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group can improve biological activity and environmental profile.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for high-performance display technologies.
• Organic Synthesis & Research: A versatile reagent for academic and industrial research in organic chemistry, enabling the introduction of fluorinated alkoxy functionalities.
• Specialty Polymer Modifier: Can be incorporated as a monomer or additive to create polymers with specific chemical resistance or surface properties.

Basic Information

Product Name	4-Difluoromethoxy-3-Ethoxy-Benzoic Acid
CAS No.	162401-63-0
Molecular Formula	C10H10F2O4
Molecular Weight	232.18 g/mol
Synonyms	3-Ethoxy-4-(difluoromethoxy)benzoic acid; Benzoic acid, 3-ethoxy-4-(difluoromethoxy)-; 4-(Difluoromethoxy)-3-ethoxybenzoic acid; 162401-63-0; DFMOBA; 3-Ethoxy-4-difluoromethoxybenzoic acid
EINECS	Contact for details

Quality Control

Every batch of 4-Difluoromethoxy-3-Ethoxy-Benzoic Acid is manufactured and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemical intermediates. Comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, is performed to verify identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment to guarantee product integrity and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials such as strong bases and oxidizing agents. The container must be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.