Description

[4-[[[1,1-Dimethylethyl)Dimethylsilyl]Oxy]Methyl]Phenylboronic Acid is a sophisticated organoboron reagent featuring a tert-butyldimethylsilyl (TBDMS) protected benzylic alcohol, which is critical for its stability and reactivity in advanced synthetic sequences. This compound matters as a key building block in modern pharmaceutical and agrochemical research, enabling precise Suzuki-Miyaura cross-coupling reactions to construct complex biaryl structures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for synthesizing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing complex biaryl motifs found in many modern drugs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides through palladium-catalyzed cross-coupling reactions.
• Material Science Research: Employed in the creation of organic electronic materials, such as polymers and small molecules for OLEDs and organic photovoltaics, where precise molecular architecture is required.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Chemical Biology & Probe Synthesis: Utilized in the preparation of molecular probes and labeled compounds for studying biological pathways and target engagement.
• Process Chemistry & Scale-up: The TBDMS protecting group offers stability, making this boronic acid suitable for multi-step synthesis and potential scale-up to pilot and commercial manufacturing.

Basic Information

Product Name	[4-[[[1,1-Dimethylethyl)Dimethylsilyl]Oxy]Methyl]Phenylboronic Acid
CAS No.	162356-89-0
Molecular Formula	C14H25BO3Si
Molecular Weight	280.25 g/mol
Synonyms	4-((tert-Butyldimethylsilyloxy)methyl)phenylboronic acid; [4-[(tert-Butyldimethylsilyloxy)methyl]phenyl]boronic acid; (4-((tert-Butyldimethylsilyloxy)methyl)phenyl)boronic acid; B-[4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]phenyl]boronic acid; 4-(TBDMS-oxymethyl)phenylboronic acid; 4-((TBDMS-O)CH2)C6H4B(OH)2; p-((tert-Butyldimethylsilanyloxy)methyl)benzeneboronic acid
EINECS	Contact for details

Quality Control

Our [4-[[[1,1-Dimethylethyl)Dimethylsilyl]Oxy]Methyl]Phenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The container should be kept tightly sealed to protect the contents from moisture.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.