Description

2-Azabicyclo[2.2.1]Heptan-3-One,5,6-Difluoro-,(Exo,Exo)-(9Ci) is a high-purity, advanced pharmaceutical intermediate characterized by its unique, rigid bicyclic structure and strategic fluorine substitution. This compound is of significant commercial importance due to its role as a key building block in the synthesis of complex, biologically active molecules, particularly in medicinal chemistry. It is primarily sought by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and antiviral therapies.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel drug candidates, particularly those targeting neurological disorders and viral infections.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its constrained geometry and fluorine atoms, which can enhance metabolic stability and binding affinity.
• Process Chemistry Development: Serves as a starting material or intermediate in the scale-up and route development for potential new chemical entities (NCEs).
• Asymmetric Synthesis: Utilized as a scaffold or chiral auxiliary in the construction of enantiomerically pure compounds for high-value applications.
• Agrochemical Research: Potential application in the development of new, high-performance crop protection agents with novel modes of action.

Basic Information

Product Name	2-Azabicyclo[2.2.1]Heptan-3-One,5,6-Difluoro-,(Exo,Exo)-(9Ci)
CAS No.	162307-10-0
Molecular Formula	C6H7F2NO
Molecular Weight	147.12 g/mol
Synonyms	(Exo,Exo)-5,6-Difluoro-2-azabicyclo[2.2.1]heptan-3-one; 5,6-Difluoro-2-azabicyclo[2.2.1]heptan-3-one, (1R,2R,4S,5R)-rel-; 2-Azabicyclo[2.2.1]heptan-3-one, 5,6-difluoro-, (1R,2R,4S,5R)-rel-; (1R,2R,4S,5R)-rel-5,6-Difluoro-2-azabicyclo[2.2.1]heptan-3-one; exo,exo-5,6-Difluoro-2-azabicyclo[2.2.1]heptan-3-one; Difluorinated 2-Azanorbornanone; 5,6-Difluoro-2-azanorbornan-3-one (exo,exo)
EINECS	Contact for details

Quality Control

Our 2-Azabicyclo[2.2.1]Heptan-3-One,5,6-Difluoro-,(Exo,Exo)-(9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC, NMR, and LC-MS, to ensure high chemical and enantiomeric purity suitable for demanding pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to handle the material under a dry inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize exposure to ambient humidity. Typical storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.