Description

4-Chloro-7-Fluoro-6-Nitro-Quinazoline is a high-purity, multi-functional heterocyclic building block of significant commercial and research interest. This compound is a key synthetic intermediate in the development of targeted pharmaceutical agents, particularly kinase inhibitors. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the synthesis of novel therapeutic compounds for oncology and other disease areas.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of tyrosine kinase inhibitors (TKIs) and other small-molecule drug candidates.
• Oncology Research: Used in medicinal chemistry for the design and development of novel anti-cancer therapeutics.
• Chemical Synthesis: Serves as a versatile building block for constructing complex quinazoline-based scaffolds in organic chemistry.
• Biochemical Research: Employed in the study of enzyme inhibition mechanisms and structure-activity relationships (SAR).
• Agrochemical Development: Potential intermediate in the research and synthesis of advanced crop protection agents.
• Material Science: Investigated for the creation of specialty chemicals and advanced functional materials.

Basic Information

Product Name	4-Chloro-7-Fluoro-6-Nitro-Quinazoline
CAS No.	162012-70-6
Molecular Formula	C8H3ClFN3O2
Molecular Weight	227.58 g/mol
Synonyms	4-Chloro-7-fluoro-6-nitroquinazoline; 6-Nitro-4-chloro-7-fluoroquinazoline; Quinazoline, 4-chloro-7-fluoro-6-nitro-; 162012-70-6; 4-Chloro-7-fluoro-6-nitro-quinazoline; 7-Fluoro-4-chloro-6-nitroquinazoline
EINECS	Contact for details

Quality Control

Our 4-Chloro-7-Fluoro-6-Nitro-Quinazoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specification parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and batch-to-batch consistency for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.