Description

4-Aminobenzoic Acid-13C6 is a stable isotope-labeled analog of para-aminobenzoic acid (PABA), where all six carbon atoms are replaced with the carbon-13 isotope. This compound is essential for use as an internal standard in quantitative mass spectrometry, providing unparalleled accuracy and reliability in analytical measurements. It is primarily required by research institutions, pharmaceutical companies, and CROs (Contract Research Organizations) engaged in advanced metabolomic studies, drug metabolism and pharmacokinetics (DMPK) research, and the development of validated bioanalytical methods.

Application

• Quantitative Mass Spectrometry (MS) Internal Standard: Serves as a critical reference compound in LC-MS/MS and GC-MS analyses for the precise quantification of endogenous PABA or related metabolites in complex biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK): Used in tracer studies to investigate the absorption, distribution, metabolism, and excretion (ADME) profiles of pharmaceutical compounds and nutrients.
• Metabolomics & Biomarker Discovery: Enables accurate profiling and relative quantification in metabolic pathway analysis, facilitating the discovery of disease biomarkers.
• Stable Isotope Dilution Assays (SIDA): Provides the labeled component for highly accurate and precise analytical methods, minimizing matrix effects and ion suppression.
• Nutritional Research: Employed in studies investigating folate metabolism and the role of PABA as a component of the vitamin B complex.
• Quality Control & Method Validation: Essential for developing and validating GLP/GMP-compliant analytical methods in pharmaceutical quality control laboratories.

Basic Information

Product Name	4-Aminobenzoic Acid-13C6
CAS No.	161406-19-5
Molecular Formula	13C6H7NO2
Molecular Weight	143.09 (based on 13C)
Synonyms	PABA-13C6; 4-Amino-13C6-benzoic Acid; para-Aminobenzoic Acid-13C6; Vitamin Bx-13C6; 4-Carboxyaniline-13C6; 4-Aminobenzoic-13C6 Acid; (13C6)-4-Aminobenzoic Acid; Benzoic-13C6 acid, 4-amino-
EINECS	Contact for details

Quality Control

Our 4-Aminobenzoic Acid-13C6 is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for critical research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically ≥99 atom % 13C), chemical purity (by HPLC), and confirming identity via spectroscopic methods. We support GLP and GMP-compliant research and can provide stability data and method validation support upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Isotopic Enrichment	≥99 atom % 13C
Chemical Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.