Description

n-(9-((2R,3R,4R,5R)-5-((Bis(4-Methoxyphenyl)(Phenyl)Methoxy)Methyl)-3,4-Bis((tert-Butyldimethylsilyl)Oxy)Tetrahydrofuran-2-Yl)-9H-Purin-6-Yl)Benzamide (Wxc08861) is a sophisticated nucleoside phosphoramidite derivative, a critical building block in the automated synthesis of oligonucleotides. Its primary value lies in enabling the precise and scalable production of DNA and RNA sequences for research and therapeutic applications. This high-purity intermediate is essential for biotechnology and pharmaceutical companies engaged in antisense therapy, siRNA development, diagnostic probe manufacturing, and synthetic biology.

Application

• Oligonucleotide Synthesis: As a key phosphoramidite monomer for the solid-phase synthesis of custom DNA and RNA strands.
• Therapeutic Development: Production of active pharmaceutical ingredients (APIs) for antisense oligonucleotides and siRNA-based drugs.
• Diagnostic Probes: Manufacturing of labeled probes for PCR, microarrays, and fluorescence in situ hybridization (FISH).
• Research Reagents: Synthesis of primers, linkers, and gene fragments for molecular biology and genetic research.
• Synthetic Biology: Construction of artificial genes and genetic circuits for advanced bioengineering projects.
• Apitamer Production: Creation of nucleic acid aptamers for targeted binding applications in diagnostics and therapeutics.

Basic Information

Item	Detail
Product Name	n-(9-((2R,3R,4R,5R)-5-((Bis(4-Methoxyphenyl)(Phenyl)Methoxy)Methyl)-3,4-Bis((tert-Butyldimethylsilyl)Oxy)Tetrahydrofuran-2-Yl)-9H-Purin-6-Yl)Benzamide (Wxc08861)
CAS No.	160513-05-3
Molecular Formula	C55H71N5O8Si2
Molecular Weight	994.37 g/mol
Synonyms	6-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N2-isobutyryl-2'-O-(tert-butyldimethylsilyl)guanosine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; dG(ib)-CE Phosphoramidite (protected with DMT and TBDMS); Guanosine Phosphoramidite Derivative; WXC08861; 6-Benzamidopurine riboside derivative; N-[(2R,3R,4R,5R)-5-[[Bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3,4-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]tetrahydrofuran-2-yl]-9H-purin-6-yl-benzamide; 2'-Deoxyguanosine phosphoramidite (DMT, TBDMS protected).
EINECS	Contact for details

Quality Control

Our n-(9-((2R,3R,4R,5R)-5-((Bis(4-Methoxyphenyl)(Phenyl)Methoxy)Methyl)-3,4-Bis((tert-Butyldimethylsilyl)Oxy)Tetrahydrofuran-2-Yl)-9H-Purin-6-Yl)Benzamide is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, critical for sensitive oligonucleotide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and moisture content. Our quality protocols are designed to meet the stringent requirements of GMP-grade pharmaceutical intermediates and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere (argon or nitrogen) due to its moisture-sensitive and light-sensitive nature. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in anhydrous acetonitrile, dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.