Description

3-Quinolinecarboxylic Acid, 6-Chloro-1-Cyclopropyl-7-Fluoro-1,4-Dihydro-4-Oxo- is a high-purity pharmaceutical intermediate of significant commercial importance. This compound serves as a critical building block in the synthesis of advanced active pharmaceutical ingredients (APIs), particularly within the fluoroquinolone antibiotic class. It is essential for manufacturers in the pharmaceutical and fine chemical industries seeking reliable, high-quality raw materials for complex synthesis pathways.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel fluoroquinolone antibacterial agents.
• Active Pharmaceutical Ingredient (API) Development: Used in research and development for creating new antibiotic compounds with improved efficacy.
• Chemical Synthesis: Serves as a versatile building block for constructing complex heterocyclic molecules in medicinal chemistry.
• Biochemical Research: Employed in studies targeting bacterial DNA gyrase and topoisomerase IV enzymes.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of antibiotic drugs.
• Reference Standard: Used as a high-purity analytical standard for quality control and regulatory submissions.

Basic Information

Product Name	3-Quinolinecarboxylic Acid, 6-Chloro-1-Cyclopropyl-7-Fluoro-1,4-Dihydro-4-Oxo-
CAS No.	160312-26-5
Molecular Formula	C13H9ClFNO3
Molecular Weight	281.67 g/mol
Synonyms	6-Chloro-1-cyclopropyl-7-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid; 1-Cyclopropyl-6-chloro-7-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; 6-Chloro-1-cyclopropyl-7-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; Quinolone Carboxylic Acid Derivative; Fluoroquinolone Intermediate; Gatifloxacin Intermediate; CAS 160312-26-5
EINECS	Contact for details

Quality Control

Our 3-Quinolinecarboxylic Acid, 6-Chloro-1-Cyclopropyl-7-Fluoro-1,4-Dihydro-4-Oxo- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5%
Single Maximum Impurity	≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.