Description

(1S,4S)-2-Oxa-5-Azabicyclo[2.2.1]Heptane Hydrobromide is a high-purity, pharmaceutically relevant chiral building block and salt form. This compound is a critical intermediate in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting neurological and cardiovascular disorders. It is essential for research and development chemists, process chemists, and manufacturers in the pharmaceutical and fine chemical industries who require a reliable source of a structurally constrained, nitrogen-oxygen heterocycle for advanced drug discovery and process optimization.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and cardiovascular targets.
• Asymmetric Synthesis: Used as a building block for constructing complex molecules with defined stereochemistry due to its rigid bicyclic structure.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs in drug discovery.
• Process Chemistry & Scale-up: Serves as a starting material or intermediate in the development and commercial-scale manufacturing of APIs.
• Chemical Biology Probes: Can be utilized to develop molecular probes for studying biological pathways and enzyme functions.
• Salt Formation Studies: The hydrobromide salt form is studied for its impact on the physicochemical properties, stability, and bioavailability of final drug substances.

Basic Information

Item	Details
Product Name	(1S,4S)-2-Oxa-5-Azabicyclo[2.2.1]Heptane Hydrobromide
CAS No.	159909-28-1
Molecular Formula	C6H10BrNO
Molecular Weight	192.05 g/mol
Synonyms	(1S,4S)-2-Oxa-5-azabicyclo[2.2.1]heptane HBr; (1S,4S)-2-Oxa-5-azabicyclo[2.2.1]heptane hydrobromide; endo-2-Oxa-5-azabicyclo[2.2.1]heptane hydrobromide; (1S,4S)-1-Aza-4-oxabicyclo[2.2.1]heptane hydrobromide; (1S,4S)-5-Azabicyclo[2.2.1]heptan-2-one, oxime, hydrobromide (related); Tropane-related bicyclic hydrobromide salt
EINECS	Contact for details

Quality Control

Our (1S,4S)-2-Oxa-5-Azabicyclo[2.2.1]Heptane Hydrobromide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP manufacturing. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.