Description

H-Tyr(Tos)-Oh is a protected tyrosine derivative, specifically O-tosyl-L-tyrosine, widely used as a critical building block in peptide synthesis. This compound is essential for researchers and manufacturers requiring precise control over side-chain reactivity during the construction of complex peptide sequences. It is primarily utilized in the pharmaceutical, biotechnology, and life science research sectors for developing novel therapeutic peptides and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of tyrosine residues with a protected phenolic hydroxyl group.
• Pharmaceutical R&D: Used in the research and development of peptide-based drugs, including hormones, antimicrobial peptides, and targeted therapeutics.
• Bioconjugation: Serves as a precursor for creating peptide conjugates for drug delivery systems, diagnostics, and biomaterials.
• Chemical Biology: Employed in the synthesis of modified peptides for studying protein-protein interactions and enzyme function.
• Custom Peptide Manufacturing: A vital raw material for CROs and CDMOs producing bespoke peptides for clients worldwide.
• Academic Research: Used in university and institutional labs for fundamental studies in peptide chemistry and medicinal chemistry.

Basic Information

Product Name	H-Tyr(Tos)-Oh
CAS No.	159505-46-1
Molecular Formula	C₁₆H₁₇NO₅S
Molecular Weight	335.38 g/mol
Synonyms	O-Tosyl-L-tyrosine; L-Tyrosine, O-(4-methylbenzenesulfonate); N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(4-methylphenylsulfonyl)-L-tyrosine; Fmoc-Tyr(Tos)-OH; Boc-Tyr(Tos)-OH; H-L-Tyr(Tos)-OH; (2S)-2-amino-3-[4-[(4-methylphenyl)sulfonyloxy]phenyl]propanoic acid; Tosyl-L-tyrosine
EINECS	Contact for details

Quality Control

Our H-Tyr(Tos)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	-10.0° to -12.0° (c=1 in DMF)
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.