Description

n-Benzyloxycarbonylglycine n-Carboxylic Anhydride is a key protected amino acid derivative used as a specialized building block in organic synthesis. This compound is critically important for the controlled, sequential formation of peptide bonds, enabling the synthesis of complex molecules with high precision. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for the development of novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental reagent for the controlled elongation of peptide chains on resin supports.
• Solution-Phase Peptide Synthesis: Used in classical coupling reactions to form specific amide bonds in solution.
• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of therapeutic peptides and related drug candidates.
• Bioconjugation Chemistry: Employed to attach peptide sequences or glycine derivatives to other biomolecules or surfaces.
• Research & Development: Essential for academic and industrial R&D focused on novel peptide structures, prodrugs, and chemical biology probes.
• Custom Synthesis Services: A key starting material for contract research and manufacturing organizations (CROs/CMOs) offering bespoke chemical synthesis.

Basic Information

Product Name	n-Benzyloxycarbonylglycine n-Carboxylic Anhydride
CAS No.	159396-61-9
Molecular Formula	C11H9NO5
Molecular Weight	235.19 g/mol
Synonyms	Z-Glycine NCA; Cbz-Glycine N-Carboxyanhydride; N-Carboxybenzyloxyglycine Anhydride; (Benzyloxycarbonyl)glycine N-Carboxylic Anhydride; Z-Gly NCA; NCA of Z-Glycine; Benzyl N-(2,5-dioxooxolan-3-yl)carbamate; N-(Benzyloxycarbonyl)glycine N-Carboxyanhydride
EINECS	Contact for details

Quality Control

Our n-Benzyloxycarbonylglycine n-Carboxylic Anhydride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for demanding synthetic applications. Each lot is analyzed using advanced techniques including HPLC, NMR, and FTIR to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation by atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Solubility	Soluble in common organic solvents (e.g., DMF, THF, DCM)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.