Description

2-Oxo-1,2,3,4-Tetrahydroquinoline-6-Carbonitrile is a high-value, nitrogen-containing heterocyclic building block of significant interest in advanced organic synthesis. Its molecular architecture, featuring a fused quinoline core with a nitrile functional group, makes it a versatile precursor for constructing complex pharmacophores. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries. It serves as a critical intermediate in the synthesis of novel active ingredients targeting a range of therapeutic and crop protection applications.

Application

• Pharmaceutical Intermediate: A key synthon for the development of quinoline-based drug candidates, potentially for central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, leveraging its heterocyclic scaffold for bioactivity.
• Material Science Precursor: Serves as a building block for organic electronic materials, dyes, and pigments due to its conjugated system and functional handles.
• Chemical Synthesis: Employed in academic and industrial R&D for constructing complex nitrogen heterocycles via reactions at the carbonyl, nitrile, or aromatic positions.
• Ligand and Catalyst Development: Potential use in designing novel chelating ligands for metal catalysis in asymmetric synthesis.

Basic Information

Product Name	2-Oxo-1,2,3,4-Tetrahydroquinoline-6-Carbonitrile
CAS No.	159053-44-8
Molecular Formula	C10H8N2O
Molecular Weight	172.18 g/mol
Synonyms	6-Cyano-3,4-dihydro-2(1H)-quinolinone; 6-Cyano-2-oxo-1,2,3,4-tetrahydroquinoline; 1,2,3,4-Tetrahydro-2-oxoquinoline-6-carbonitrile; 2-Oxo-1,2,3,4-tetrahydroquinoline-6-carbonitrile; Quinoline-6-carbonitrile, 1,2,3,4-tetrahydro-2-oxo-; 6-CN-THQ; 159053-44-8
EINECS	Contact for details

Quality Control

Our 2-Oxo-1,2,3,4-Tetrahydroquinoline-6-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or production specifications. Custom purity grades and analytical packages are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0% (Standard Grade)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.