Description

4-Iodo-L-Phenylalanine Methyl Ester, Hydrochloride is a halogenated, non-natural amino acid derivative of significant interest in advanced organic synthesis and pharmaceutical research. This compound serves as a crucial chiral building block for the development of novel peptide-based therapeutics and diagnostic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, particularly for the synthesis of targeted radiopharmaceuticals and as a precursor for complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of peptide-based drugs and targeted therapies.
• Radiopharmaceutical Precursor: Used in the synthesis of iodine-123 or iodine-131 labeled compounds for diagnostic imaging and therapeutic applications.
• Medicinal Chemistry Research: Employed as a building block for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Peptide Modification: Facilitates the site-specific incorporation of iodine into peptide sequences to study protein interactions or create novel bioconjugates.
• Chemical Biology Probes: Acts as a precursor for developing activity-based probes and other tools for biochemical and cellular studies.

Basic Information

Product Name	4-Iodo-L-Phenylalanine Methyl Ester, Hydrochloride
CAS No.	158686-46-5
Molecular Formula	C10H13ClINO2
Molecular Weight	341.57 g/mol
Synonyms	L-Phenylalanine, 4-iodo-, methyl ester, hydrochloride; Methyl (2S)-2-amino-3-(4-iodophenyl)propanoate hydrochloride; 4-Iodo-L-Phe-OMe·HCl; (S)-Methyl 2-amino-3-(4-iodophenyl)propanoate hydrochloride; Methyl L-4-iodophenylalaninate hydrochloride; p-Iodo-L-phenylalanine methyl ester hydrochloride; 4-Iodo-L-phenylalanine methyl ester HCl
EINECS	Contact for details

Quality Control

Our 4-Iodo-L-Phenylalanine Methyl Ester, Hydrochloride is manufactured under strict quality control protocols to ensure high chemical purity and batch-to-batch consistency suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients in regulated development pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.