Description

tert-Butyl 6-Bromospiro[Indene-1,4'-Piperidine]-1'-Carboxylate is a high-value, advanced pharmaceutical intermediate featuring a complex spirocyclic indene-piperidine scaffold. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel bioactive molecules. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing new therapeutic agents, particularly in central nervous system (CNS) and oncology drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Protease Inhibitor Development: The spirocyclic structure is valuable for creating novel inhibitors for enzymes like kinases or proteases.
• CNS Drug Discovery: The piperidine moiety makes it relevant for developing compounds that interact with neurological targets.
• Chemical Biology Probes: Serves as a starting point for creating molecular probes to study biological processes and protein function.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific synthetic routes.
• Library Synthesis: Used to generate diverse chemical libraries for high-throughput screening in early-stage drug discovery.

Basic Information

Product Name	tert-Butyl 6-Bromospiro[Indene-1,4'-Piperidine]-1'-Carboxylate
CAS No.	158628-80-9
Molecular Formula	C18H22BrNO2
Molecular Weight	364.28 g/mol
Synonyms	1'-Boc-6-bromospiro[indene-1,4'-piperidine]; 6-Bromo-1'-[(tert-butoxy)carbonyl]spiro[indene-1,4'-piperidine]; tert-Butyl 6-bromo-1,4-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate; 6-Bromospiro[indene-1,4'-piperidine]-1'-carboxylic acid tert-butyl ester; 1,4-Dihydrospiro[indene-1,4'-piperidine]-1'-carboxylic acid, 6-bromo-, 1,1-dimethylethyl ester; Boc-6-Bromo-spiro(indene-1,4'-piperidine); 6-Bromo-1'-Boc-spiro[indene-1,4'-piperidine]; 158628-80-9
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-Bromospiro[Indene-1,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and cGMP-grade production to meet the stringent requirements of pharmaceutical R&D and pre-clinical studies.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.