Description

3-Chloro-4-(Trifluoromethoxy)Nitrobenzene is a high-purity, multi-functional aromatic intermediate of significant importance in advanced organic synthesis. Its unique structure, featuring chloro, nitro, and trifluoromethoxy substituents, makes it a versatile building block for creating complex molecules with tailored properties. This compound is primarily sought after by R&D chemists and process development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a trifluoromethoxy-phenyl backbone.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers and liquid crystals.
• Dye and Pigment Intermediate: Employed in the synthesis of complex organic dyes and pigments, leveraging the nitro group for further chemical transformations.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) to construct biaryl systems for various applications.

Basic Information

Product Name	3-Chloro-4-(Trifluoromethoxy)Nitrobenzene
CAS No.	158579-81-8
Molecular Formula	C7H3ClF3NO3
Molecular Weight	241.55 g/mol
Synonyms	1-Chloro-2-nitro-4-(trifluoromethoxy)benzene; 2-Nitro-4-(trifluoromethoxy)chlorobenzene; 3-Chloro-4-(trifluoromethoxy)-1-nitrobenzene; 4-(Trifluoromethoxy)-3-chloronitrobenzene; 3-Chloro-α,α,α-trifluoro-4-nitroanisole; Nitro(trifluoromethoxy)chlorobenzene
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-(Trifluoromethoxy)Nitrobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency meet the high standards required for synthetic applications. Certificates of Analysis (COA) documenting all critical parameters are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.