Description

Acetic Acid, 2-[2-[2-[2-(2-Chloroethoxy)Ethoxy]Ethoxy]Ethoxy]- is a specialized, multi-armed polyethylene glycol (PEG) derivative featuring a terminal chloro group and an acetic acid moiety. This unique bifunctional structure makes it a versatile chemical building block for creating custom linkers, spacers, and functionalized polymers. It is primarily utilized by R&D and production chemists in the pharmaceutical, biotechnology, and advanced materials sectors for applications requiring precise molecular design and controlled conjugation.

Application

• Pharmaceutical Linker Chemistry: Serves as a heterobifunctional crosslinker for conjugating drugs, peptides, or targeting ligands to antibodies, proteins, or nanoparticles.
• PEGylation Reagent: Used to introduce hydrophilic PEG chains onto therapeutic molecules or surfaces to improve solubility, stability, and circulation time.
• Polymer Synthesis: Acts as a functional monomer or initiator for creating tailored co-polymers with specific chain-end functionality for drug delivery systems.
• Surface Modification: Employed to functionalize materials and biosensor surfaces with reactive groups for subsequent biomolecule immobilization.
• Intermediate for Further Derivatization: The chloro and carboxylic acid groups provide orthogonal reactivity for sequential chemical modifications to create complex architectures.

Basic Information

Product Name	Acetic Acid, 2-[2-[2-[2-(2-Chloroethoxy)Ethoxy]Ethoxy]Ethoxy]-
CAS No.	158553-98-1
Molecular Formula	C14H27ClO7
Molecular Weight	342.81 g/mol
Synonyms	2-[2-[2-[2-(2-Chloroethoxy)ethoxy]ethoxy]ethoxy]acetic acid; Acetic acid, 2,2'-[oxybis(2,1-ethanediyloxy)]bis-, 1,1'-[2-chloroethyl)imino]bis-; PEG4-chloroacetic acid; Tetraethylene glycol monochlorohydrin acetic acid ester; α-Chloro-ω-carboxymethoxy tetraethylene glycol; 2,5,8,11-Tetraoxatetradecan-14-oic acid, 13-chloro-; Chloro-PEG4-acid
EINECS	Contact for details

Quality Control

Every batch of Acetic Acid, 2-[2-[2-[2-(2-Chloroethoxy)Ethoxy]Ethoxy]Ethoxy]- is produced under a strict quality management system. We employ advanced analytical techniques including HPLC, NMR, and titration to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing assay, impurity profile, and other critical parameters is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.