Description

Fmoc-D-Thr-Oh CAS NO 157355-81-2 is a high-purity, protected amino acid derivative essential for solid-phase peptide synthesis (SPPS). Its core value lies in providing the D-isomer of threonine with an Fmoc-protected α-amino group, enabling precise, racemization-free incorporation into complex peptide sequences. This building block is critically needed by pharmaceutical R&D teams, biotech companies, and CROs engaged in the development of therapeutic peptides, peptidomimetics, and novel bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental building block for the automated, stepwise construction of custom peptide chains using Fmoc-chemistry protocols.
• Therapeutic Peptide Development: Used in the research and production of peptide-based pharmaceuticals, including hormones, antimicrobial peptides, and targeted therapeutics.
• Peptidomimetic & Drug Discovery: Serves as a key chiral scaffold for creating modified peptide structures with enhanced stability, bioavailability, or receptor affinity.
• Bioconjugation & Labeling: The reactive carboxylic acid group allows for site-specific conjugation to other molecules, carriers, or fluorescent tags.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Academic & Industrial Research: A standard reagent in biochemistry and organic chemistry laboratories for studying protein structure-function relationships and enzyme specificity.

Basic Information

Product Name	Fmoc-D-Thr-Oh
CAS No.	157355-81-2
Molecular Formula	C19H19NO5
Molecular Weight	341.36 g/mol
Synonyms	Fmoc-D-threonine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-threonine; (2R,3S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-hydroxybutanoic acid; D-Threonine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; Fmoc-D-Thr-OH; N-Fmoc-D-threonine; (R,S)-Fmoc-threonine (D-form); Fmoc-D-Thr
EINECS	Contact for details

Quality Control

Our Fmoc-D-Thr-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically meeting standards suitable for pharmaceutical research. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to relevant industry guidelines to support our customers' compliance needs in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	Specific range available on COA
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.