Description

4-Chloro-7-Trifluoromethyl-Quinoline-3-Carbonitrile is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its core value lies in the strategic combination of reactive sites—the chloro, trifluoromethyl, and nitrile groups—which enable precise molecular diversification. This compound is critically needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors, antiviral agents, and other biologically active quinoline-based compounds.
• Agrochemical Research: Used to develop novel herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing trifluoromethyl group.
• Material Science: Serves as a building block for creating advanced organic electronic materials, such as OLED (Organic Light-Emitting Diode) components and charge-transport materials.
• Chemical Synthesis: Utilized in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic substitution reactions to construct complex molecular architectures.
• Fluorine Chemistry: An important substrate for studying the effects of fluorine substitution on the physical and chemical properties of quinoline derivatives.

Basic Information

Product Name	4-Chloro-7-Trifluoromethyl-Quinoline-3-Carbonitrile
CAS No.	157301-81-0
Molecular Formula	C11H4ClF3N2
Molecular Weight	256.61 g/mol
Synonyms	4-Chloro-7-(trifluoromethyl)quinoline-3-carbonitrile; 3-Cyano-4-chloro-7-(trifluoromethyl)quinoline; 7-Trifluoromethyl-4-chloroquinoline-3-carbonitrile; 4-Chloro-7-trifluoromethylquinoline-3-carbonitrile; 157301-81-0; Quinoline-3-carbonitrile, 4-chloro-7-(trifluoromethyl)-; 4-Chloro-7-trifluoromethyl-3-quinolinecarbonitrile
EINECS	Contact for details

Quality Control

Our 4-Chloro-7-Trifluoromethyl-Quinoline-3-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.