Description

(S)-α-Methoxy-2-Naphthaleneacetic Acid, (S)-2-NMA is a high-purity chiral non-steroidal anti-inflammatory drug (NSAID) intermediate. It is a critical building block in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), where its defined stereochemistry is essential for biological activity. This compound is primarily required by pharmaceutical R&D and manufacturing sectors for the development of novel therapeutics, particularly in the production of (S)-Naproxen and other optically active arylpropionic acid derivatives.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of (S)-Naproxen, a widely prescribed NSAID.
• API Manufacturing: Used in the production of other enantiomerically pure non-steroidal anti-inflammatory drugs and analgesics.
• Asymmetric Synthesis: Serves as a valuable chiral synthon or resolving agent in organic and medicinal chemistry research.
• Biochemical Research: Utilized in studies investigating enzyme inhibition, receptor binding, and the pharmacological effects of chiral molecules.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(S)-α-Methoxy-2-Naphthaleneacetic Acid, (S)-2-NMA
CAS No.	157134-51-5
Molecular Formula	C₁₄H₁₄O₃
Molecular Weight	230.26 g/mol
Synonyms	(S)-2-(6-Methoxynaphthalen-2-yl)propanoic Acid; (S)-Naproxen Intermediate; (S)-2-(6-Methoxy-2-naphthyl)propionic Acid; (S)-MNA; L-Naproxen Intermediate; (S)-α-Methyl-6-methoxy-2-naphthaleneacetic Acid; (2S)-2-(6-Methoxynaphthalen-2-yl)propanoic Acid
EINECS	Contact for details

Quality Control

Our (S)-α-Methoxy-2-Naphthaleneacetic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and related substances are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.