Description

4-[3-(Trifluoromethyl)-3H-Diazirin-3-Yl]Phenol is a specialized diazirine-based photoaffinity labeling reagent. This compound is valued for its ability to form highly reactive carbene intermediates upon photolysis, enabling the covalent cross-linking and study of biomolecular interactions. It is primarily utilized by researchers and manufacturers in the fields of chemical biology, proteomics, and pharmaceutical development for target identification and binding site mapping.

Application

• Photoaffinity Labeling (PAL): A critical tool for studying protein-ligand, protein-protein, and protein-nucleic acid interactions by forming irreversible covalent bonds upon UV light activation.
• Proteomics Research: Used to identify and characterize unknown binding sites and targets for drug candidates and bioactive small molecules.
• Chemical Probe Development: Incorporated into probe molecules to enable the capture and isolation of specific biological targets from complex mixtures.
• Structural Biology: Assists in mapping the topology of binding pockets and understanding molecular recognition events.
• Material Science: Potential use in surface functionalization and creating photo-crosslinkable polymers or coatings.
• Bioconjugation: Serves as a photoreactive handle for attaching molecules to surfaces, nanoparticles, or other biomolecules.

Basic Information

Product Name	4-[3-(Trifluoromethyl)-3H-Diazirin-3-Yl]Phenol
CAS No.	156824-51-0
Molecular Formula	C9H5F3N2O
Molecular Weight	214.14 g/mol
Synonyms	3-(4-Hydroxyphenyl)-3-(trifluoromethyl)-3H-diazirine; 3-(4-Hydroxyphenyl)-3-(trifluoromethyl)diazirine; 4-(3-Trifluoromethyl-3H-diazirin-3-yl)phenol; p-(3-(Trifluoromethyl)-3H-diazirin-3-yl)phenol; TFD-Phenol; Photoaffinity Labeling Phenol Reagent; Diazirine-Phenol Crosslinker
EINECS	Contact for details

Quality Control

Our production of 4-[3-(Trifluoromethyl)-3H-Diazirin-3-Yl]Phenol adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and stability is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. Keep the container in a dry, cool, and well-ventilated place. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.