Description

2S,3S,5S-2,5-Diamino-3-Hydroxy-1,6-Diphenylhexane, Dihydrochloride is a high-purity, stereochemically defined chiral building block and pharmaceutical intermediate. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of complex molecules where specific stereochemistry is essential for biological activity. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions focused on peptidomimetics and novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for cardiovascular and central nervous system (CNS) targets.
• Peptidomimetic Synthesis: Serves as a constrained scaffold for designing and synthesizing peptide analogs to improve metabolic stability and bioavailability.
• Asymmetric Catalysis Research: Used as a ligand precursor or a chiral auxiliary in the development of stereoselective synthetic methodologies.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Biochemical Research: Investigated for its potential interactions with biological receptors and enzymes in mechanistic studies.
• Fine Chemical Production: Integrated into multi-step synthetic routes for the manufacture of specialized, high-value fine chemicals.

Basic Information

Product Name	2S,3S,5S-2,5-Diamino-3-Hydroxy-1,6-Diphenylhexane, Dihydrochloride
CAS No.	156769-85-6
Molecular Formula	C18H26Cl2N2O
Molecular Weight	357.32 g/mol
Synonyms	(2S,3S,5S)-2,5-Diamino-3-hydroxy-1,6-diphenylhexane dihydrochloride; (2S,3S,5S)-2,5-Diamino-3-hydroxy-1,6-diphenylhexane hydrochloride; 1,6-Diphenyl-2,5-diamino-3-hexanol dihydrochloride (2S,3S,5S)-; (2S,3S,5S)-1,6-Diphenylhexane-2,5-diamine-3-ol dihydrochloride; 156769-85-6; A-84538 dihydrochloride (stereoisomer); Chiral diphenylhexanediamine derivative HCl salt
EINECS	Contact for details

Quality Control

Our 2S,3S,5S-2,5-Diamino-3-Hydroxy-1,6-Diphenylhexane, Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) providing batch-specific results for identity, purity, and impurities is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (2S,3S,5S-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.