Description

(2S,3R)-3-(n-Boc-Amino)-1-Oxirane-4-Phenylbutane CAS NO 156474-22-5 is a high-purity, chiral epoxide building block protected with a tert-butoxycarbonyl (Boc) group. This compound matters as a critical synthetic intermediate for constructing complex molecules with defined stereochemistry, enabling the development of targeted pharmaceuticals and bioactive compounds. It is primarily needed by research institutions and pharmaceutical companies engaged in the synthesis of peptide mimetics, protease inhibitors, and other advanced active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates, particularly protease inhibitors and renin inhibitors.
• Peptidomimetic Chemistry: Used to introduce constrained, non-natural amino acid residues into peptide chains to enhance metabolic stability and bioavailability.
• Asymmetric Synthesis: Serves as a versatile electrophile in nucleophilic ring-opening reactions to create new carbon-nitrogen and carbon-oxygen bonds with stereochemical control.
• API Development: Employed in research and process chemistry for the development and scale-up of potential Active Pharmaceutical Ingredients (APIs).
• Chemical Biology Probes: Useful for labeling and modifying biomolecules to study biological pathways and protein function.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.

Basic Information

Product Name	(2S,3R)-3-(n-Boc-Amino)-1-Oxirane-4-Phenylbutane
CAS No.	156474-22-5
Molecular Formula	C₁₇H₂₅NO₄
Molecular Weight	307.38 g/mol
Synonyms	(2S,3R)-1,2-Epoxy-3-[(tert-butoxycarbonyl)amino]-4-phenylbutane; (2S,3R)-3-[(tert-Butoxycarbonyl)amino]-1,2-epoxy-4-phenylbutane; (2S,3R)-3-(Boc-Amino)-1,2-epoxy-4-phenylbutane; (2S,3R)-N-Boc-3-amino-1,2-epoxy-4-phenylbutane; (2S,3R)-1-Oxirane-4-phenyl-3-[(2-methyl-2-propanyl)oxy]carbonyl]amino]butane; Boc-Aminoepoxide Phenylbutane Derivative; Chiral Boc-Protected Amino Epoxide
EINECS	Contact for details

Quality Control

Our (2S,3R)-3-(n-Boc-Amino)-1-Oxirane-4-Phenylbutane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for advanced synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.