Description

Indolizine, 8-Fluorooctahydro-1,6,7-Tris(Phenylmethoxy)-, 1S-(1.Alpha.,6.Beta.,7.Alpha.,8.Beta.,8A.Beta.)- is a complex, multi-functional organic compound with a defined stereochemistry, serving as a critical advanced pharmaceutical intermediate or research chemical. Its intricate structure, featuring fluorinated and benzyl-protected hydroxyl groups, makes it a valuable building block for the synthesis of specialized molecules in medicinal chemistry. This compound is primarily targeted at pharmaceutical R&D and fine chemical synthesis sectors, where precise stereochemistry and high purity are paramount for developing new active ingredients.

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and antiviral research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its unique fluorinated indolizine scaffold.
• Process Chemistry Development: Serves as a standard or reference material for scaling up synthetic routes in pilot plants.
• Academic & Institutional Research: Employed in universities and research institutes for studying fluorination effects and stereoselective reactions.
• Fine Chemical Synthesis: Precursor for creating more complex, high-value specialty chemicals with specific biological activity.
• Contract Manufacturing (CMO/CDMO): Supplied to contract organizations engaged in custom synthesis for clinical trial material production.

Basic Information

Product Name	Indolizine, 8-Fluorooctahydro-1,6,7-Tris(Phenylmethoxy)-, 1S-(1.Alpha.,6.Beta.,7.Alpha.,8.Beta.,8A.Beta.)-
CAS No.	156150-90-2
Molecular Formula	C30H33FO3
Molecular Weight	460.58 g/mol
Synonyms	(1S,6R,7S,8R,8aR)-8-Fluoro-1,6,7-tris(benzyloxy)octahydroindolizine; 8-Fluoro-1,6,7-tris-O-(phenylmethyl)-1S,6R,7S,8R,8aR-octahydroindolizine; 8-Fluorooctahydro-1,6,7-tris(phenylmethoxy)indolizine (1S,6β,7α,8β,8aβ)-; 156150-90-2; Fluorinated Indolizine Derivative; Tris-O-benzyl Fluorinated Indolizine
EINECS	Contact for details

Quality Control

Every batch of this high-purity intermediate is produced and analyzed under strict quality management protocols. We provide comprehensive Certificates of Analysis (COA) that detail identity, purity, and impurity profiles, ensuring traceability and compliance with cGMP standards where required. Our quality systems are designed to meet the stringent demands of pharmaceutical development, supporting regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The compound is sensitive to strong acids and organic solvents; keep away from incompatible materials. For long-term storage, consider under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single unknown impurity ≤ 1.0%
Optical Rotation	Contact for details
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.