Description

2,2-Difluoro-1-Phenylcyclopropanecarboxylic Acid CAS NO 156021-07-7 is a high-value fluorinated cyclopropane derivative, a crucial synthetic intermediate in modern organic chemistry. Its unique structure, featuring a difluorocyclopropane ring fused to a phenylcarboxylic acid, makes it an essential building block for introducing conformational rigidity and fluorine atoms into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, metabolic diseases, and anti-infective agents.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the fluorinated cyclopropane moiety can enhance biological activity and environmental stability.
• Material Science Research: Serves as a monomer or building block for creating specialty polymers and advanced materials with unique thermal or chemical resistance properties.
• Ligand and Catalyst Development: Employed in the design of novel chiral ligands and organocatalysts for asymmetric synthesis applications.
• Chemical Biology Probes: Utilized to create fluorinated analogs of natural products or bioactive molecules for mechanism-of-action studies and diagnostic applications.
• Academic & Contract Research: A valuable reagent for methodological development and exploration of new fluorination and cyclopropanation reactions in university and CRO laboratories.

Basic Information

Product Name	2,2-Difluoro-1-Phenylcyclopropanecarboxylic Acid
CAS No.	156021-07-7
Molecular Formula	C10H8F2O2
Molecular Weight	198.17 g/mol
Synonyms	2,2-Difluoro-1-phenylcyclopropane-1-carboxylic acid; 1-Phenyl-2,2-difluorocyclopropanecarboxylic acid; α,α-Difluoro-β-phenylcyclopropanecarboxylic acid; 2,2-Difluorocyclopropanecarboxylic acid, 1-phenyl-; Difluorophenylcyclopropanecarboxylic acid; DFPC Acid; 156021-07-7 (CAS)
EINECS	Contact for details

Quality Control

Every batch of 2,2-Difluoro-1-Phenylcyclopropanecarboxylic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements of your synthetic route. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by HPLC/NMR), identity confirmation, and impurity profiles. Our quality commitment supports applications requiring GMP-grade starting materials and compliance with REACH regulations.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.