Description

(R)-(S)-Josiphos CAS NO 155806-35-2 is a highly versatile and efficient chiral diphosphine ligand, a cornerstone in modern asymmetric catalysis. Its primary value lies in enabling the synthesis of enantiomerically pure compounds, which are critical for the development of pharmaceuticals and advanced materials. This ligand is essential for research institutions and industrial manufacturers engaged in asymmetric hydrogenation, hydroformylation, and other transition metal-catalyzed reactions.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones, crucial for producing chiral intermediates in active pharmaceutical ingredients (APIs).
• Pharmaceutical Synthesis: Used in the production of key chiral building blocks for a wide range of therapeutics, including cardiovascular, central nervous system (CNS), and antiviral drugs.
• Agrochemical Manufacturing: Enables the synthesis of enantiomerically pure herbicides, fungicides, and pesticides with improved efficacy and environmental profiles.
• Fine Chemical Production: Applied in the synthesis of specialty chemicals, flavors, and fragrances where high enantiomeric purity is required.
• Academic & Process R&D: A standard tool in research laboratories for developing new catalytic methodologies and optimizing synthetic routes.
• Catalyst Screening Libraries: Serves as a key component in high-throughput screening kits for identifying optimal catalytic conditions.

Basic Information

Product Name	(R)-(S)-Josiphos
CAS No.	155806-35-2
Molecular Formula	C31H26FeP2
Molecular Weight	516.33 g/mol
Synonyms	(R)-1-[(S)-2-(Diphenylphosphino)ferrocenyl]ethyldicyclohexylphosphine; (R)-(S)-PPF-PCy2; Josiphos SL-J009-1; (R)-(S)-JOSIPHOS; Ferrocenylphosphine ligand J009-1; (R)-1-[(S)-2-(Diphenylphosphino)ferrocenyl]ethyl-di-cyclohexylphosphine; (1R)-1-[(SP)-2-(Diphenylphosphanyl-kP)ferrocen-1-yl]ethyl-di(cyclohexyl)phosphane; JOSIPHOS-type ligand
EINECS	Contact for details

Quality Control

Our (R)-(S)-Josiphos is manufactured under strict quality management systems to ensure batch-to-batch consistency and high performance. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and chiral analysis to verify enantiomeric purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. This compound is light-sensitive and easily oxidized; prolonged exposure to air or light may degrade performance.

Specification

Item	Specification
Appearance	Orange to red-brown powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity	≥ 99.0% ee
Solubility	Soluble in common organic solvents (Toluene, DCM, THF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.