Description

n-[(3R)-1-(3,3-Dimethyl-2-Oxobutyl)-2,3-Dihydro-2-Oxo-5-(2-Pyridinyl)-1H-1,4-Benzodiazepin-3-Yl]-N'-[3-(Methylamino)Phenyl]Urea is a high-purity, non-peptidic small molecule antagonist of the human oxytocin receptor (OTR). This compound matters as a critical research tool for investigating the physiological and behavioral roles of oxytocin signaling, which is implicated in social bonding, stress response, and reproductive functions. Pharmaceutical R&D teams and academic researchers in neuropharmacology and endocrinology require this specific antagonist for target validation, in vitro and in vivo studies, and the development of novel therapeutic agents for conditions like autism, anxiety, and preterm labor.

Application

• Pharmacological Research: Used as a selective, high-affinity antagonist in competitive binding assays to characterize the oxytocin receptor (OTR).
• Neuroscience Studies: Essential for in vivo behavioral research to block central oxytocin pathways and study effects on social recognition, anxiety, and maternal behavior.
• Drug Discovery & Development: Serves as a reference compound and a chemical starting point for the design and optimization of new OTR-targeting therapeutics.
• Endocrine System Research: Applied in studies investigating the role of oxytocin in uterine contraction, lactation, and cardiovascular regulation.
• Biochemical Assay Development: Utilized as a standard to validate and calibrate high-throughput screening (HTS) platforms for OTR activity.
• Academic & Clinical Research: Supports fundamental research into the pathophysiology of psychiatric and neurodevelopmental disorders.

Basic Information

Product Name	n-[(3R)-1-(3,3-Dimethyl-2-Oxobutyl)-2,3-Dihydro-2-Oxo-5-(2-Pyridinyl)-1H-1,4-Benzodiazepin-3-Yl]-N'-[3-(Methylamino)Phenyl]Urea
CAS No.	155488-25-8
Molecular Formula	C28H30N6O4
Molecular Weight	514.58 g/mol
Synonyms	L-371,257; L371257; Oxytocin Receptor Antagonist L-371,257; (R)-N-{1-[3,3-Dimethyl-1-(2-oxo-2-phenylethyl)-2-oxobutyl]-2-oxo-5-(pyridin-2-yl)-2,3-dihydro-1H-1,4-benzodiazepin-3-yl}-N'-[3-(methylamino)phenyl]urea; (3R)-N-[1-(3,3-Dimethyl-2-oxobutyl)-2,3-dihydro-2-oxo-5-(2-pyridinyl)-1H-1,4-benzodiazepin-3-yl]-N'-[3-(methylamino)phenyl]urea; SSR-126768A (Note: SSR-126768 is a related analog); Non-peptide Oxytocin Antagonist.
EINECS	Contact for details

Quality Control

Our n-[(3R)-1-(3,3-Dimethyl-2-Oxobutyl)-2,3-Dihydro-2-Oxo-5-(2-Pyridinyl)-1H-1,4-Benzodiazepin-3-Yl]-N'-[3-(Methylamino)Phenyl]Urea is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and potency, meeting the high standards required for pharmacological research. A comprehensive Certificate of Analysis (COA) detailing results for assay, chiral purity, and related substances is provided with every shipment to guarantee reproducible and reliable performance in your experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This compound is hygroscopic (moisture-sensitive). For long-term storage, consider under an inert atmosphere. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (R-enantiomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.