Description

Boc-Dl-5-Methyl-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid, 98 CAS NO 155367-45-6 is a protected amino acid derivative featuring a tetrahydroisoquinoline scaffold, a privileged structure in medicinal chemistry. This compound is a critical high-purity building block for the synthesis of complex molecules, offering researchers precise control over stereochemistry and functional group manipulation. It is primarily needed by pharmaceutical R&D and contract research organizations (CROs) engaged in developing novel therapeutic agents, particularly in the areas of central nervous system (CNS) and oncology drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of potential drug candidates targeting various disease pathways.
• Peptidomimetic Research: Used to incorporate constrained, non-natural amino acid motifs into peptide backbones to enhance metabolic stability and receptor selectivity.
• Chemical Biology Probe Development: Employed in the construction of molecular probes and tool compounds for studying enzyme function and protein-protein interactions.
• Library Synthesis for High-Throughput Screening: A valuable input for generating focused combinatorial libraries based on the biologically relevant tetrahydroisoquinoline core.
• Academic Research: Utilized in universities and research institutes for methodological studies in asymmetric synthesis and heterocyclic chemistry.
• Process Chemistry Development: Acts as a starting material or intermediate for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.

Basic Information

Item	Detail
Product Name	Boc-Dl-5-Methyl-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid, 98
CAS No.	155367-45-6
Molecular Formula	C16H21NO4
Molecular Weight	291.34 g/mol
Synonyms	tert-Butyl (DL)-5-methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylate; N-Boc-5-methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; Boc-5-methyl-Tic-OH; (RS)-3-[(tert-Butoxycarbonyl)amino]-5-methyl-3,4-dihydro-1H-isoquinoline-3-carboxylic acid; 5-Methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid N-Boc derivative; DL-5-Methyl-Tic(Boc)-OH; BOC-DL-5-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYLIC ACID
EINECS	Contact for details

Quality Control

Our Boc-Dl-5-Methyl-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided and available upon request, supporting compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.