Description

(2S,3S)- 3-Hydroxy-2-Pyrrolidinemethanol Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate. This compound is valued for its defined stereochemistry and functional groups, which are critical for synthesizing enantiomerically pure active pharmaceutical ingredients (APIs). It is primarily sought by research institutions and manufacturers in the pharmaceutical and fine chemical industries for the development of novel therapeutics and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of enantiomerically pure drugs, particularly in central nervous system (CNS) and antiviral research.
• Asymmetric Synthesis: Used as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce stereoselectivity.
• Peptidomimetics & Proline Analogue Synthesis: Serves as a constrained scaffold for designing peptide mimics and modified amino acids with enhanced metabolic stability.
• Agrochemical Research: Employed in the development of chiral pesticides and herbicides where specific stereochemistry impacts biological activity.
• Academic & Process Chemistry: A valuable reagent for methodological development in organic chemistry and scale-up process optimization.

Basic Information

Product Name	(2S,3S)- 3-Hydroxy-2-Pyrrolidinemethanol Hydrochloride
CAS No.	154278-84-9
Molecular Formula	C5H12ClNO2
Molecular Weight	153.61 g/mol
Synonyms	(2S,3S)-3-Hydroxy-2-(hydroxymethyl)pyrrolidine hydrochloride; (2S,3S)-2-(Hydroxymethyl)-3-pyrrolidinol hydrochloride; (3S,4S)-4-(Hydroxymethyl)-3-pyrrolidinol hydrochloride; (2S,3S)-3-Hydroxy-2-pyrrolidinemethanol HCl; (2S,3S)-2-Pyrrolidinemethanol, 3-hydroxy-, hydrochloride; L-threo-3-Hydroxy-2-pyrrolidinemethanol hydrochloride
EINECS	Contact for details

Quality Control

Our (2S,3S)- 3-Hydroxy-2-Pyrrolidinemethanol Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) providing specifications for identity, purity, and impurities is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.