Description

L-2-(Boc-Amino)-3-(2'-Methoxybiphenyl-4-Yl)Propanoic Acid is a protected amino acid derivative featuring a biphenyl moiety, serving as a crucial chiral building block in advanced organic synthesis. Its primary value lies in enabling the controlled introduction of a complex, sterically hindered aromatic side chain during peptide and peptidomimetic construction. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical industry developing novel therapeutic agents, particularly for applications in medicinal chemistry and drug discovery programs.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of peptide-based drugs and bioactive molecules targeting various disease pathways.
• Peptidomimetic Research: Used to incorporate non-natural, aromatic amino acid analogs into peptide chains to enhance stability, bioavailability, and receptor binding affinity.
• Medicinal Chemistry: Serves as a versatile building block in structure-activity relationship (SAR) studies and the development of protease inhibitors or GPCR modulators.
• API Development: Employed in the research and scale-up phases of active pharmaceutical ingredient (API) synthesis requiring specific chiral centers and complex aromatic systems.
• Chemical Biology Probes: Utilized in the creation of labeled or modified peptides for studying biological processes and protein-protein interactions.

Basic Information

Product Name	L-2-(Boc-Amino)-3-(2'-Methoxybiphenyl-4-Yl)Propanoic Acid
CAS No.	154116-45-7
Molecular Formula	C21H25NO5
Molecular Weight	371.43 g/mol
Synonyms	Boc-2'-Methoxybiphenyl-4-ylalanine; (S)-2-((tert-Butoxycarbonyl)amino)-3-(2'-methoxy-[1,1'-biphenyl]-4-yl)propanoic acid; N-Boc-2'-Methoxybiphenyl-4-yl-L-alanine; N-(tert-Butoxycarbonyl)-2'-methoxybiphenyl-4-yl-L-alanine; L-2-(tert-Butoxycarbonylamino)-3-(2'-methoxybiphenyl-4-yl)propionic Acid; Boc-(2'-MeO-Bip-4-yl)-Ala-OH; 154116-45-7
EINECS	Contact for details

Quality Control

Our L-2-(Boc-Amino)-3-(2'-Methoxybiphenyl-4-Yl)Propanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with high-grade pharmaceutical intermediate standards. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.