Description

Dirhodium Tetrakis[n-Phthaloyl-(S)-tert-Leucinate] Bis(Ethyl Acetate) Adduct is a highly specialized chiral dirhodium(II) carboxylate catalyst, a cornerstone for asymmetric synthesis in modern organic chemistry. This compound matters because it enables highly enantioselective C-H functionalization, cyclopropanation, and other carbenoid transfer reactions critical for constructing complex molecular architectures. Pharmaceutical, agrochemical, and fine chemical R&D laboratories require this catalyst to develop novel active ingredients and advanced materials with precise stereochemical control.

Application

• Asymmetric C-H Amination: A key catalyst for the enantioselective insertion of nitrenes into C-H bonds to synthesize chiral amines.
• Enantioselective Cyclopropanation: Used to construct chiral cyclopropane rings, a vital structural motif in many bioactive compounds.
• Carbenoid Insertion Reactions: Facilitates Si-H and other X-H insertions with high stereoselectivity for functional group introduction.
• Pharmaceutical Intermediate Synthesis: Critical for the R&D and scale-up of chiral drug candidates, including APIs for central nervous system and antiviral therapies.
• Agrochemical Product Development: Employed in creating enantiomerically pure herbicides, fungicides, and pesticides with improved efficacy and environmental profiles.
• Methodology Development in Academia: A standard reagent in university and institutional labs for developing new catalytic asymmetric transformations.
• Fine Chemical and Fragrance Synthesis: Used to produce high-value, optically pure flavors, fragrances, and specialty chemicals.

Basic Information

Product Name	Dirhodium Tetrakis[n-Phthaloyl-(S)-tert-Leucinate] Bis(Ethyl Acetate) Adduct
CAS No.	154090-43-4
Molecular Formula	C68H68N4O20Rh2 • 2(C4H8O2)
Molecular Weight	Contact for details
Synonyms	Dirhodium(II) Tetrakis[(S)-N-phthaloyl-tert-leucinate]; Rh2(S-PTTL)4; Rh2(S-PTTL)4•2(EtOAc); (S)-Dirhodium Tetrakis(α-phthalimido-tert-leucinate); Dirhodium(II) Carboxylate Catalyst; Chiral Dirhodium Catalyst; Rh2(S-PTTL)4 Adduct; Asymmetric Dirhodium Catalyst
EINECS	Contact for details

Quality Control

Our Dirhodium Tetrakis[n-Phthaloyl-(S)-tert-Leucinate] Bis(Ethyl Acetate) Adduct is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, NMR, and elemental analysis, to ensure high catalytic activity and enantiomeric purity. Certificates of Analysis (COA) detailing identity, purity, and specific performance characteristics are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere (argon or nitrogen) due to its sensitivity to moisture and oxidation. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	Green to dark green crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity	≥ 99.0% ee
Rhodium Content	Within theoretical range
Solvent Content (Residual Solvents)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.