Description

5-(4-Fluoro-Phenyl)-1H-Pyrrole-2-Carboxylic Acid is a high-purity fluorinated pyrrole derivative, a crucial heterocyclic building block in advanced organic synthesis. Its core value lies in its unique molecular scaffold, which combines a fluorinated aromatic ring with a pyrrole carboxylic acid, enabling precise structural modifications for developing novel active compounds. This intermediate is essential for research and development chemists in the pharmaceutical and agrochemical sectors, particularly for creating new drug candidates and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), especially in therapeutic areas targeting inflammation, central nervous system (CNS) disorders, and metabolic diseases.
• Agrochemical Research: Serves as a core structure for synthesizing new-generation herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the fluorine atom.
• Material Science Precursor: Used in the synthesis of specialized polymers, organic semiconductors, and advanced functional materials requiring fluorinated heterocyclic components.
• Chemical Biology & Proteomics: Employed as a building block for designing molecular probes, enzyme inhibitors, and labeled compounds for biochemical research.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences industry.

Basic Information

Product Name	5-(4-Fluoro-Phenyl)-1H-Pyrrole-2-Carboxylic Acid
CAS No.	153783-33-6
Molecular Formula	C11H8FNO2
Molecular Weight	205.19 g/mol
Synonyms	5-(4-Fluorophenyl)-1H-pyrrole-2-carboxylic acid; 2-Pyrrolecarboxylic acid, 5-(4-fluorophenyl)-; 4-Fluoro-5-(1H-pyrrol-2-yl)benzoic acid; 153783-33-6; 5-(p-Fluorophenyl)-1H-pyrrole-2-carboxylic acid; 5-(4-Fluorophenyl)pyrrole-2-carboxylic acid; 1H-Pyrrole-2-carboxylic acid, 5-(4-fluorophenyl)-; 5-(4-Fluorophenyl)-2-carboxypyrrole
EINECS	Contact for details

Quality Control

Our production of 5-(4-Fluoro-Phenyl)-1H-Pyrrole-2-Carboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. Our quality system supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.