Description

o-(2-Trimethylsilylethyl)Hydroxylamine Hydrochloride is a specialized organosilicon-protected hydroxylamine derivative, serving as a critical reagent for the controlled introduction of the hydroxylamine functional group. This compound is particularly valuable for its role as a key building block in the synthesis of complex molecules, especially within pharmaceutical research and development. It is primarily utilized by synthetic organic chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly for introducing N-O functionality in a protected manner.
• Peptide and Protein Modification: Used in chemical biology for the site-specific modification of amino acids, enabling the study of protein function and interaction.
• Polymer Chemistry: Acts as a functional monomer or chain transfer agent in the synthesis of specialty polymers with tailored surface properties.
• Agrochemical Synthesis: Employed in the development of new herbicides, fungicides, and insecticides that require hydroxylamine-based active ingredients or intermediates.
• Cross-coupling Reactions: Serves as a nitrogen source in palladium-catalyzed amination reactions for constructing C-N bonds.
• Material Science Research: Used in surface functionalization of silicon-based materials and nanoparticles for sensor development and catalysis.

Basic Information

Product Name	o-(2-Trimethylsilylethyl)Hydroxylamine Hydrochloride
CAS No.	153502-27-3
Molecular Formula	C5H16ClNOSi
Molecular Weight	169.73 g/mol
Synonyms	N-[(Trimethylsilyl)ethyl]hydroxylamine hydrochloride; 2-((Trimethylsilyl)ethyl)hydroxylamine hydrochloride; O-(2-Trimethylsilylethyl)hydroxylamine HCl; (2-Trimethylsilylethyl)hydroxylamine hydrochloride; Hydroxylamine, O-[2-(trimethylsilyl)ethyl]-, hydrochloride; TMS-Ethyl Hydroxylamine Hydrochloride; N-Hydroxy-2-(trimethylsilyl)ethanamine hydrochloride
EINECS	Contact for details

Quality Control

Our o-(2-Trimethylsilylethyl)Hydroxylamine Hydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and Karl Fischer titration, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.