Description

3-{[(tert-Butoxycarbonyl)Amino]Methyl}-4-Chlorobenzoic Acid is a high-purity, protected amino acid derivative that serves as a critical building block in modern organic synthesis. This compound matters because it provides a versatile chiral intermediate with orthogonal protecting groups, enabling precise and efficient construction of complex molecules. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptides, and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used for the incorporation of modified phenylalanine analogs into peptide chains during solid-phase or solution-phase peptide synthesis.
• Protecting Group Strategy: The tert-butoxycarbonyl (Boc) group allows for selective deprotection under mild acidic conditions, facilitating multi-step synthetic sequences.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological processes and enzyme mechanisms.
• Agrochemical Research: Acts as an intermediate in the development of new herbicides, fungicides, and plant growth regulators.

Basic Information

Product Name	3-{[(tert-Butoxycarbonyl)Amino]Methyl}-4-Chlorobenzoic Acid
CAS No.	153346-57-7
Molecular Formula	C14H18ClNO4
Molecular Weight	299.75 g/mol
Synonyms	4-Chloro-3-((((tert-butoxy)carbonyl)amino)methyl)benzoic acid; 3-((Boc-amino)methyl)-4-chlorobenzoic acid; 3-(Boc-aminomethyl)-4-chlorobenzoic acid; Boc-4-Cl-Phe-OH (common abbreviation); (4-Chloro-3-((((2-methyl-2-propanyl)oxy)carbonyl)amino)methyl)benzoic acid; tert-Butyl N-[(4-chloro-3-carboxyphenyl)methyl]carbamate; Benzoic acid, 4-chloro-3-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-
EINECS	Contact for details

Quality Control

Our 3-{[(tert-Butoxycarbonyl)Amino]Methyl}-4-Chlorobenzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our commitment to quality supports applications requiring high standards, including cGMP development and research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.