Description

2-o-(5-Bromo-4-Chloroindol-3-Yl)Sialic Acid CAS NO 153248-52-3 is a specialized, high-purity synthetic derivative of sialic acid, a critical carbohydrate moiety in glycobiology research. This compound is engineered as a key biochemical tool for the study and inhibition of sialidases (neuraminidases) and other sialic acid-recognizing proteins. It is primarily utilized by research scientists and pharmaceutical developers in the fields of glycobiology, virology, and oncology for probing disease mechanisms and developing novel therapeutic agents.

Application

• Biochemical Research: Serves as a potent and selective inhibitor in enzymatic studies of viral, bacterial, and mammalian neuraminidases.
• Antiviral Drug Discovery: Used as a reference standard or a synthetic intermediate in the development of novel neuraminidase inhibitors targeting influenza and other viruses.
• Cancer Research: Employed to investigate the role of sialylation in cancer cell signaling, metastasis, and immune evasion.
• Glycoconjugate Synthesis: Acts as a building block for the chemical or enzymatic synthesis of complex glycans and glycoproteins for structural and functional studies.
• Diagnostic Development: Utilized in the design and calibration of assays for detecting sialidase activity or sialic acid-binding lectins.
• Microbiology Studies: Applied in research on bacterial pathogens that utilize sialic acids for host cell adhesion and colonization.

Basic Information

Product Name	2-o-(5-Bromo-4-Chloroindol-3-Yl)Sialic Acid
CAS No.	153248-52-3
Molecular Formula	C19H22BrClN2O9
Molecular Weight	529.74 g/mol
Synonyms	5-Bromo-4-chloro-3-indolyl α-D-N-acetylneuraminate; 2-O-(5-Bromo-4-chloro-3-indolyl)-α-D-N-acetylneuraminic acid; 5-Bromo-4-chloroindol-3-yl α-sialoside; BCI-Sialic Acid; Neu5Ac-α-(5-Br-4-Cl-Ind); Glycosidase inhibitor 153248-52-3; Sialidase inhibitor derivative
EINECS	Contact for details

Quality Control

Every batch of 2-o-(5-Bromo-4-Chloroindol-3-Yl)Sialic Acid is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We adhere to high-purity research-grade standards, with quality verified by advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 3.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.