Description

4-Amino-2,2-dimethylbutanoic acid hydrochloride is a high-purity, protected amino acid derivative essential for advanced organic synthesis. This compound matters as a critical chiral building block, offering a sterically hindered, primary amine functionality for constructing complex molecular architectures. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers for applications in peptide mimetics, active pharmaceutical ingredient (API) development, and the synthesis of specialized bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents and active pharmaceutical ingredients (APIs).
• Peptidomimetics & Constrained Peptides: Used to introduce the non-proteinogenic 2,2-dimethylbutanoic acid (Dmb) side chain, enhancing metabolic stability and modulating peptide conformation.
• Protecting Group Strategy: Serves as a precursor where the amino group, protected as its hydrochloride salt, can be selectively deprotected for further functionalization.
• Ligand & Catalyst Synthesis: Employed in the preparation of specialized ligands for asymmetric catalysis and metal complexes.
• Bioconjugation & Linker Chemistry: Useful for creating chemical linkers in antibody-drug conjugates (ADCs) or other bioconjugation platforms.
• Academic & Industrial Research: A valuable tool for medicinal chemistry and chemical biology research exploring structure-activity relationships (SAR).

Basic Information

Product Name	4-Amino-2,2-Dimethylbutanoic Acid Hydrochloride
CAS No.	153039-15-7
Molecular Formula	C6H14ClNO2
Molecular Weight	167.63 g/mol
Synonyms	Dmb-Gly-OH·HCl; 2,2-Dimethyl-4-aminobutanoic Acid Hydrochloride; 4-Amino-2,2-dimethylbutyric Acid Hydrochloride; (4-Amino-2,2-dimethylbutanoyl)glycine Hydrochloride; Fmoc-Dmb-OH (related protected form); 2-Amino-4,4-dimethylpentanoic Acid Hydrochloride (isomer); 153039-15-7; 4-Amino-Dmb-OH·HCl
EINECS	Contact for details

Quality Control

Our 4-Amino-2,2-dimethylbutanoic acid hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after use to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.