Description

Tetrabutylazanium:Fluoride:Hydrate is a specialized quaternary ammonium fluoride salt, recognized for its utility as a potent fluoride ion source and phase-transfer catalyst. This compound is particularly valued in advanced organic synthesis for its ability to facilitate challenging fluorination and desilylation reactions under mild conditions. It serves as a critical reagent for R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors, where precise fluorination is required.

Application

• As a fluoride ion source for nucleophilic fluorination reactions in pharmaceutical intermediate synthesis.
• As a desilylating agent for the selective removal of silyl protecting groups in complex multi-step organic syntheses.
• As a phase-transfer catalyst (PTC) in biphasic reaction systems to enhance reaction rates and yields.
• In the research and development of fluorinated organic compounds and specialty chemicals.
• For the preparation of radioactive fluorine-18 labeled compounds used in Positron Emission Tomography (PET) imaging agent development.
• In materials science for the surface modification or etching of silicon-containing substrates.

Basic Information

Product Name	Tetrabutylazanium:Fluoride:Hydrate
CAS No.	153005-55-1
Molecular Formula	C₁₆H₃₆FN • xH₂O
Molecular Weight	Contact for details
Synonyms	Tetrabutylammonium Fluoride Hydrate; TBAF Hydrate; Tetra-n-butylammonium Fluoride Hydrate; Azanium, N,N,N-tributylbutyl-, fluoride, hydrate (1:1:?); Fluorotetrabutylammonium Hydrate; Tetrabutylazanium Fluoride Monohydrate; Tetrabutylammonium Fluoride Solution Solid Alternative
EINECS	Contact for details

Quality Control

Our Tetrabutylazanium:Fluoride:Hydrate is manufactured under controlled conditions to ensure batch-to-batch consistency and high chemical purity. Quality is verified through a suite of analytical techniques including NMR, HPLC, and Karl Fischer titration. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and water content is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of activity.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Assay (TBAF basis)	≥ 95.0%
Water Content (KF)	Specified on COA
Related Impurities (HPLC)	≤ 1.0% total

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.