Description

(1R,2R,4S)-Rel-7-Boc-7-Azabicyclo[2.2.1]Heptan-2-Ol CAS NO 152533-46-5 is a high-purity, stereochemically defined bicyclic amine derivative, serving as a critical chiral building block and advanced pharmaceutical intermediate. Its value lies in providing a rigid, three-dimensional scaffold essential for constructing complex molecules with precise spatial orientation, which is paramount for modern drug discovery. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral therapies.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, especially those targeting neurological receptors.
• Asymmetric Synthesis: Utilized as a versatile scaffold for constructing enantiomerically pure compounds in medicinal chemistry.
• Protease Inhibitor Development: Serves as a core structural element in the research and development of protease inhibitors.
• Ligand and Catalyst Preparation: Used to prepare chiral ligands for asymmetric catalysis and organometallic complexes.
• Chemical Biology Probes: Employed in the design of molecular probes to study enzyme function and biological pathways.
• Peptidomimetics: Incorporated into peptide-like structures to enhance metabolic stability and bioavailability.

Basic Information

Product Name	(1R,2R,4S)-Rel-7-Boc-7-Azabicyclo[2.2.1]Heptan-2-Ol
CAS No.	152533-46-5
Molecular Formula	C11H19NO3
Molecular Weight	213.27 g/mol
Synonyms	(1R,2R,4S)-rel-7-(tert-Butoxycarbonyl)-7-azabicyclo[2.2.1]heptan-2-ol; 7-Boc-7-azabicyclo[2.2.1]heptan-2-ol, (1R,2R,4S)-rel-; (1R,2R,4S)-7-Boc-2-Hydroxy-7-azabicyclo[2.2.1]heptane; endo-(1R,2R,4S)-7-(tert-Butoxycarbonyl)-7-azabicyclo[2.2.1]heptan-2-ol; Boc-7-Azanorbornanol; tert-Butyl (1R,2R,4S)-2-hydroxy-7-azabicyclo[2.2.1]heptane-7-carboxylate; 7-Azabicyclo[2.2.1]heptan-2-ol, 7-[(1,1-dimethylethoxy)carbonyl]-, (1R,2R,4S)-rel-; Chiral 7-Azabicyclo[2.2.1]heptane Building Block
EINECS	Contact for details

Quality Control

Our (1R,2R,4S)-Rel-7-Boc-7-Azabicyclo[2.2.1]Heptan-2-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for research and cGMP applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.