Description

21-Chloro-21-Iodovinylestradiol is a halogenated derivative of the natural estrogen hormone estradiol, designed for advanced research and pharmaceutical development. This compound matters as a key synthetic intermediate and a potential molecular probe for studying steroid hormone receptor interactions and metabolic pathways. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel endocrine therapies, diagnostic agents, and in-depth biochemical studies.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel steroidal drugs and targeted therapeutic agents.
• Biochemical Research: Used as a molecular probe to investigate estrogen receptor (ER) binding affinity, selectivity, and downstream signaling mechanisms.
• Metabolic Pathway Studies: Employed in research to trace and understand the metabolic fate and transformation of halogenated steroids.
• Diagnostic Agent Development: Acts as a precursor for developing radiolabeled or contrast agents for imaging applications in endocrinology.
• Academic & Industrial R&D: Utilized in universities and corporate labs for fundamental studies in medicinal chemistry and steroid pharmacology.

Basic Information

Product Name	21-Chloro-21-Iodovinylestradiol
CAS No.	151986-79-7
Molecular Formula	C20H24ClIO2
Molecular Weight	458.76 g/mol
Synonyms	21-Chloro-21-iodovinylestradiol; Estra-1,3,5(10)-triene-3,17-diol, 21-chloro-21-iodovinyl-; (17β)-21-Chloro-21-iodovinylestra-1,3,5(10)-triene-3,17-diol; 21-Chloro-21-iodovinyl-estradiol; 21-Cl-21-I-vinylestradiol; Halogenated Vinylestradiol Derivative
EINECS	Contact for details

Quality Control

Our 21-Chloro-21-Iodovinylestradiol is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, and specifications can be aligned with client requirements for advanced pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is light-sensitive (store away from light). For long-term storage, consider storing under an inert atmosphere in a freezer (-20°C) to maximize stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.