Description

5(3H)-Indolizinone,8,8A-Dihydro-,(8As)-(9Ci) is a specialized chiral indolizinone derivative, a high-value synthetic intermediate of significant interest in advanced organic synthesis. Its unique fused bicyclic structure and defined stereochemistry make it a critical building block for constructing complex molecular architectures. This compound is primarily utilized by research institutions and pharmaceutical development companies engaged in the discovery of novel active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key chiral scaffold in the research and development of new therapeutic agents, particularly for central nervous system (CNS) and anti-inflammatory targets.
• Asymmetric Synthesis: Employed as a sophisticated starting material or intermediate in catalytic asymmetric reactions to introduce stereogenic centers.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to explore novel chemical space.
• Heterocyclic Chemistry: Acts as a versatile precursor for the synthesis of more complex nitrogen-containing heterocycles with potential biological activity.
• Academic & Industrial R&D: Utilized in chemical research for methodology development and the synthesis of natural product analogs or novel molecular libraries.

Basic Information

Product Name	5(3H)-Indolizinone,8,8A-Dihydro-,(8As)-(9Ci)
CAS No.	151983-41-4
Molecular Formula	C8H9NO
Molecular Weight	135.16 g/mol
Synonyms	(8aS)-8,8a-Dihydro-5(3H)-indolizinone; (8aS)-5,8,8a,9-Tetrahydroindolizin-3-one; (8aS)-Octahydroindolizin-3-one; (8aS)-3-Indolizinone, 8,8a-dihydro-; 151983-41-4; (8aS)-Dihydro-5(3H)-indolizinone; (8aS)-5,8,8a,9-Tetrahydro-3H-indolizin-3-one
EINECS	Contact for details

Quality Control

Our high-purity chemical intermediates are produced and handled under strict quality management protocols. Each batch of 5(3H)-Indolizinone,8,8A-Dihydro-,(8As)-(9Ci) undergoes comprehensive analytical characterization, including chiral purity verification, to ensure consistency and reliability for research applications. A detailed Certificate of Analysis (COA) providing purity, chiral excess, and identification data is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.