Description

3-Bromo-1-Trityl-1H-1,2,4-Triazole is a high-value, protected heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in providing a versatile and reactive brominated triazole scaffold that is shielded by a trityl protecting group, enabling selective functionalization for the construction of complex molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients, ligands, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting kinases and other enzymes where the 1,2,4-triazole moiety is pharmacologically active.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that incorporate heterocyclic structures for enhanced efficacy.
• Ligand and Catalyst Development: Serves as a building block for creating specialized N-heterocyclic carbene (NHC) precursors, chelating ligands, and organocatalysts.
• Material Science Research: Employed in the synthesis of advanced polymers, dyes, and photoactive materials that require functionalized triazole units.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create more complex molecular architectures.
• Chemical Biology & Proteomics: Useful for synthesizing probes, tags, and linkers for studying biological systems and protein interactions.

Basic Information

Product Name	3-Bromo-1-Trityl-1H-1,2,4-Triazole
CAS No.	151899-63-7
Molecular Formula	C21H16BrN3
Molecular Weight	390.28 g/mol
Synonyms	1-Trityl-3-bromo-1H-1,2,4-triazole; 3-Bromo-1-trityl-1,2,4-triazole; 3-Bromo-1-(triphenylmethyl)-1H-1,2,4-triazole; 1H-1,2,4-Triazole, 3-bromo-1-(triphenylmethyl)-; Triphenylmethyl 3-bromo-1,2,4-triazole; Trityl-protected 3-bromotriazole
EINECS	Contact for details

Quality Control

Our 3-Bromo-1-Trityl-1H-1,2,4-Triazole is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive analytical data including HPLC purity, NMR, and mass spectrometry for identity confirmation. A Certificate of Analysis (COA) detailing all specifications is available with every shipment and upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat and incompatible materials. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.