Description

3-(Difluoromethyl)-1H-Pyrazole-4-Carboxylic Acid is a high-purity, functionalized pyrazole derivative serving as a critical building block in advanced organic synthesis. Its value lies in the difluoromethyl group, which is a key bioisostere used to modulate the physicochemical and metabolic properties of target molecules. This compound is essential for R&D and production chemists in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients with improved efficacy and stability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting metabolic diseases, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and manufacture of modern crop protection agents, such as fungicides and herbicides, where the difluoromethyl moiety enhances biological activity and environmental profile.
• Chemical Research & Development: Serves as a versatile scaffold in academic and industrial R&D for exploring new chemical entities and reaction pathways.
• Material Science Precursor: Potential use in the synthesis of specialized polymers or ligands with unique electronic properties.

Basic Information

Product Name	3-(Difluoromethyl)-1H-Pyrazole-4-Carboxylic Acid
CAS No.	151734-02-0
Molecular Formula	C5H4F2N2O2
Molecular Weight	162.10 g/mol
Synonyms	3-(Difluoromethyl)-1H-pyrazole-4-carboxylic acid; 1H-Pyrazole-4-carboxylic acid, 3-(difluoromethyl)-; 4-Carboxy-3-(difluoromethyl)pyrazole; 3-Difluoromethyl-1H-pyrazole-4-carboxylic acid; DFMPA; Difluoromethylpyrazolecarboxylic Acid
EINECS	Contact for details

Quality Control

Every batch of 3-(Difluoromethyl)-1H-Pyrazole-4-Carboxylic Acid is manufactured under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity consistent with industry and customer specifications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.